Title :
Nano liquid handling with bio-actuated micro heart pump powered by cardiomyocytes sheet
Author :
Morishima, Keisuke ; Tanaka, Yo ; Shimizu, Tatsuya ; Yamato, Masayuki ; Kikuchi, Akihiko ; Okano, Teruo ; Kitamori, Takehiko
Author_Institution :
Dept. of Mech. Syst. Eng., Univ. of Agric. & Technol., Tokyo, Japan
Abstract :
We have succeeded in the creation of a new fluid handling system in a microspace using cultured cardiomyocytes as a component of a micropump. In order to communicate the force generated by cardiomyocytes to fluid, a thin diaphragm and a push bar structure made of PDMS were assembled onto a microchannel and cardiomyocytes sheet was attached on them. Estimated flow rate of this micropump was 52 nL/min. The applied pressure on the diaphragm generated by cardiomyocytes was 2Pa. This is the first demonstration of microheart pump using cardiomyocytes sheet only by chemical energy without electrical power supply.
Keywords :
biomechanics; cardiology; cellular biophysics; microactuators; microchannel flow; micropumps; nanotechnology; 2 Pa; PDMS; bio-actuated micro heart pump; cardiomyocytes; cardiomyocytes sheet; chemical energy; flow rate; fluid handling system; microchannel; microheart pump; micropump; microspace; nanoliquid handling; push bar structure; thin diaphragm; Assembly; Cardiology; Chemical technology; Heart; Microchannel; Micropumps; Polyimides; Power engineering and energy; Pumps; Valves;
Conference_Titel :
Nanotechnology, 2005. 5th IEEE Conference on
Print_ISBN :
0-7803-9199-3
DOI :
10.1109/NANO.2005.1500676
