• DocumentCode
    1857891
  • Title

    Micro-Molded Cannulae for Intracochlear Infusions in Small Rodents

  • Author

    Johnson, D.G. ; Xiao Xia Zhu ; Frisina, R.D. ; Borkholder, David A.

  • Author_Institution
    Rochester Inst. of Technol., Rochester
  • fYear
    2007
  • fDate
    22-26 Aug. 2007
  • Firstpage
    6616
  • Lastpage
    6619
  • Abstract
    The design, fabrication, and testing of micro- cannulae with integrated insertion stops is presented. The micro-cannulae were engineered through the use of a silicon micro-mold fabricated via bulk-silicon micro-machining techniques. The use of microelectronic fabrication techniques allows precise control of three critical parameters, insertion depth, interface contact area, and tubing out of round. Worst case variations were found to be 5mum for insertion depth, 502mum2 for interface contact area, and 7% for tip out of round. Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani.
  • Keywords
    bioMEMS; drug delivery systems; ear; micromachining; prosthetics; bulk silicon micromachining technique; insertion depth; integrated insertion stops; interface contact area; intracochlear infusions; microelectronic fabrication technique; micromolded cannulae; rodents; scala tympani; Curing; Dentistry; Etching; Fabrication; Mice; Rodents; Shape control; Sheet materials; Silicon; Size control; Cannulae; Drug Delivery Device; Implantable Device; Microfabrication; Micromolding; Mouse; Animals; Catheterization; Cochlea; Drug Delivery Systems; Mice; Mice, Inbred CBA; Miniaturization; Resins, Synthetic; Silicone Elastomers;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
  • Conference_Location
    Lyon
  • ISSN
    1557-170X
  • Print_ISBN
    978-1-4244-0787-3
  • Type

    conf

  • DOI
    10.1109/IEMBS.2007.4353876
  • Filename
    4353876