Title :
Micro-Molded Cannulae for Intracochlear Infusions in Small Rodents
Author :
Johnson, D.G. ; Xiao Xia Zhu ; Frisina, R.D. ; Borkholder, David A.
Author_Institution :
Rochester Inst. of Technol., Rochester
Abstract :
The design, fabrication, and testing of micro- cannulae with integrated insertion stops is presented. The micro-cannulae were engineered through the use of a silicon micro-mold fabricated via bulk-silicon micro-machining techniques. The use of microelectronic fabrication techniques allows precise control of three critical parameters, insertion depth, interface contact area, and tubing out of round. Worst case variations were found to be 5mum for insertion depth, 502mum2 for interface contact area, and 7% for tip out of round. Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani.
Keywords :
bioMEMS; drug delivery systems; ear; micromachining; prosthetics; bulk silicon micromachining technique; insertion depth; integrated insertion stops; interface contact area; intracochlear infusions; microelectronic fabrication technique; micromolded cannulae; rodents; scala tympani; Curing; Dentistry; Etching; Fabrication; Mice; Rodents; Shape control; Sheet materials; Silicon; Size control; Cannulae; Drug Delivery Device; Implantable Device; Microfabrication; Micromolding; Mouse; Animals; Catheterization; Cochlea; Drug Delivery Systems; Mice; Mice, Inbred CBA; Miniaturization; Resins, Synthetic; Silicone Elastomers;
Conference_Titel :
Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Conference_Location :
Lyon
Print_ISBN :
978-1-4244-0787-3
DOI :
10.1109/IEMBS.2007.4353876