The Activation Function of TMS on a Finite Element Model of a Cortical Sulcus

Author

Silva, S. ; Basser, P.J. ; Miranda, P.C.

Author_Institution

Univ. of Lisbon, Lisbon

fYear

2007

fDate

22-26 Aug. 2007

Firstpage

6656

Lastpage

6659

Abstract

TMS is a promising tool for the non-invasive stimulation of the cerebral cortex, with applications in neurology and the neurosciences. From cable theory, it is known that the activation function for neuronal stimulation in TMS may contain contributions from the electric field and the component of the electric field gradient along the direction of the nerve. Here we present a calculation of the spatial distribution of the induced electric field by TMS using a finite element model of the cerebral cortex and surrounding tissues. This distribution allows us to calculate the activation function for different experimental conditions, and is expected to provide new insight into the mechanisms of TMS in the cortex.

Keywords

bioelectric phenomena; biomagnetism; brain; finite element analysis; neurophysiology; patient diagnosis; physiological models; TMS activation function; cerebral cortex; cortical sulcus; electric field gradient; finite element model; neurological pathology diagnosis; neurology; neuronal stimulation; neurosciences; noninvasive stimulation; Biomembranes; Biophysics; Brain modeling; Cerebral cortex; Electric potential; Equations; Finite element methods; Magnetic fields; Nerve fibers; Nervous system; Cerebral Cortex; Electric Stimulation; Finite Element Analysis; Models, Neurological; Transcranial Magnetic Stimulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE

Conference_Location

Lyon

ISSN

1557-170X

Print_ISBN

978-1-4244-0787-3

Type

conf

DOI

10.1109/IEMBS.2007.4353886

Filename

4353886