Title :
Molecular aspects of the interaction between glutathione and DNA
Author :
Rix-Montel, Marie-Agnes ; Kranck, Hubert ; Vasilescu, Dan
Author_Institution :
Lab. de Biophys., Nice Univ., France
Abstract :
After evaluating electrical and mechanical mobilities of the tripeptide glutathione, a monoanion (GSH-) at pH 7, the authors present spectrophotometric results in the ultraviolet range concerning interaction between DNA and GSH. No marked action is observed at the characteristic wavelength (258 nm) of native DNA, but changes in the shapes of the DNA thermal denaturation curve are found. The intricate behavior of DNA-GSH thermal transconformation is discussed
Keywords :
DNA; molecular biophysics; ultraviolet spectra of organic molecules and substances; 258 nm; DNA; UV spectrophotometry; characteristic wavelength; electrical mobility; mechanical mobility; molecular interaction; monoanion; thermal denaturation curve; thermal transconformation; tripeptide glutathione; Biomedical optical imaging; DNA; In vitro; In vivo; Injuries; Laboratories; Lipidomics; Optical noise; Shape; Temperature;
Conference_Titel :
Engineering in Medicine and Biology Society, 1989. Images of the Twenty-First Century., Proceedings of the Annual International Conference of the IEEE Engineering in
Conference_Location :
Seattle, WA
DOI :
10.1109/IEMBS.1989.96396
