3D capillary vessel and arteriole simulator fabricated by using femtosecond laser and mask hybrid exposure

Blood vessel simulators can contribute to development of endovascular treatment techniques. However, most of the blood vessel model, whose diameter is smaller than 500 μm, of conventional simulators is fabricated by using mask exposure, and the microfluidic network is limited in the two dimensional plane. Here, we propose fabrication method of arbitral three-dimensional (3D) vessel simulators whose diameter is smaller than 500 μm. We employ 3D exposure method using femtosecond laser and mask hybrid exposure(FMEx). FMEx makes it possible to fabricate a millimeter-sized large structure with submicrometer resolution in three dimensions. In this paper, we fabricated 3D capillary vessel and arteriole simulator with two branches by using FMEx.