Design of biointerface for high-performance biodevice

Non-biofouling surfaces constitute one of the most important subjects for applications of materials and devices under biological environments. Poly(ethylene glycol) (PEG) chains tethered on substrate surfaces are well known to reduce non-biofouling characteristics. Protein adsorption onto a PEG-chain-tethered surface is strongly influenced by the density of the PEG chain and is almost completely suppressed by the successive treatment of longer PEG chains followed by the treatment of PEG (mixed-PEG-chain-tethered surface) because of a significant increase in PEG chain density. Multipoint anchoring of PEG was confirmed to increase the stability of the surface polymer significantly, while mono-functional-ended PEG showed not only lower stability but also lowered packing density. New surface-modification strategy for suppression of blood cell activation will be also proposed.