Title :
A monolithically integrated platform for high throughput cell characterization and drug screening
Author :
Ji, Xu ; Yang, Lin ; Wei, Zewen ; Wang, Lu ; Xi, Jianzhong ; Li, Zhihong
Author_Institution :
Nat. Key Lab. of Micro/Nano Fabrication Technol., Peking Univ., Beijing, China
Abstract :
Real-time physiological properties´ characterization of living cells is important for bio-engineering applications such as drug screening. In this paper, we propose an integrated platform to automatically characterize muscle cell mechanics under a variety of culture conditions and drug stimuli in parallel. A Post-CMOS process is developed to fabricate the integrated chip, and then living muscle cells self-assembled on the surface directed by the gold pattern. Preliminary experiment validates feasibility of the procedure. Finally, chip-level packaging is performed using a PDMS cap and a plastic tube.
Keywords :
bioMEMS; biological techniques; biomedical engineering; cellular biophysics; lab-on-a-chip; microfluidics; muscle; PDMS cap; bioengineering applications; chip level packaging; culture conditions; drug stimuli; high throughput cell characterization; high throughput drug screening; integrated chip fabrication; monolithically integrated platform; muscle cell mechanics; plastic tube; post-CMOS process; real time cellular physiological property characterization; self assembled living muscle cells; Biomedical monitoring; CMOS process; Circuits; Drugs; Fabrication; Microfluidics; Micromechanical devices; Muscles; Piezoresistance; Throughput; cell characterization; drug screening; monolithical integration; self-assembly;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285720
