Title :
Non-polymer coated Fe3O4 aqueous dispersion with NH3+-surface modification as new magnetite nanoparticles and their biomedical applications
Author :
Cheng, F.Y. ; Shieh, D.B. ; Yeh, C.S.
Author_Institution :
Dept. of Chem., Nat. Cheng Kung Univ., Tainan, Taiwan
Abstract :
Well-dispersed Fe3O4 nanoparticles were synthesized using chemical coprecipitation and the addition of organic acid as adherent in an aqueous solution. The resulting iron oxide particles were manipulated as small as 6 nm diameter in size. The nanoparticles exhibit cationic surface mostly decorated with terminal -NH3+. The in vitro cytotoxicity test revealed excellent biocompatibility to further explore for their potential in vivo applications. NMR measurements showed significantly reduced water proton relaxation times T1 and T2. The MR images of the nanoparticles in water and serum were then investigated using 1.5 T clinical MR imager.
Keywords :
biomagnetism; biomedical MRI; disperse systems; iron compounds; nanoparticles; nanotechnology; nitrogen compounds; nuclear magnetic resonance; precipitation; 1.5 T; 6 nm; Fe3O4; NH3; NH3+-surface modification; NMR measurements; biocompatibility; biomedical applications; cationic surface; chemical coprecipitation; clinical MR imager; in vitro cytotoxicity; magnetite nanoparticles; nonpolymer coated Fe3O4 aqueous dispersion; water proton relaxation times; Biochemistry; Electrons; In vitro; Iron; Magnetic materials; Magnetic resonance imaging; Nanoparticles; Superconducting magnets; Surface morphology; Surface treatment;
Conference_Titel :
Nanotechnology, 2005. 5th IEEE Conference on
Print_ISBN :
0-7803-9199-3
DOI :
10.1109/NANO.2005.1500833
