Design and characterization of a multiplexed capillary-driven lab-on-chip for water quality analysis

Author

Honrado, Carlos ; Silva, C.A. ; Tao Dong

Author_Institution

Dept. of Ind. Electron., Univ. of Minho, Guimarães, Portugal

fYear

2014

fDate

11-12 June 2014

Firstpage

1

Lastpage

6

Abstract

The concept of a novel point-of-care (POC) microfluidic device for water-quality analysis was presented. The device employs capillary phenomena as filling process and its design is compatible to the use of organic photodiodes for bio-sensing. Three different device conformations were described and characterized. The series model attained a small total filling time (TFT) of around 2.80s. However, as disadvantage, this conformation cannot be used in bio-chemiluminescence (BCL) reactions having multiple analytes in common. For the parallel model, a high TFT of around 86s was obtained and some advancing/receding of fluid during the filling process was observed. This could lead to weaker optical signals and higher noise in the sensing area. Regarding the parallel-series, a TFT value of 35s was attained. This is a compromise between previously studied conformations. Also, no advancing/receding of fluid has occurred and a more compact design was created, as desired for POC applications.

Keywords

bioMEMS; biochemistry; biomedical equipment; biomedical measurement; capillarity; chemiluminescence; design; lab-on-a-chip; microfluidics; patient care; photodiodes; water quality; BCL reactions; POC applications; POC microfluidic device; TFT value; biochemiluminescence reactions; biosensing; capillary phenomena; compact design; device conformations; filling process; fluid advancing occurrence; fluid receding occurrence; lab-on-chip characterization; multiple analytes; multiplexed capillary-driven lab-on-chip design; noise; organic photodiodes; parallel model; parallel-series; point-of-care microfluidic device; series model; time 35 s; total filling time; water quality analysis; weak optical signals; Atmospheric modeling; Filling; Fluids; Microchannel; Microfluidics; Optical sensors; bio-chemiluminescence; capillary phenomena; microfluidics; point-of-care; polymer photodiode; water quality analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Medical Measurements and Applications (MeMeA), 2014 IEEE International Symposium on

Conference_Location

Lisboa

Print_ISBN

978-1-4799-2920-7

Type

conf

DOI

10.1109/MeMeA.2014.6860084

Filename

6860084