Title :
A quadrupolar magnetic actuation system for superparamagnetic particles
Author :
Moser, Y. ; Lehnert, T. ; Gijs, M.A.M.
Author_Institution :
Lab. of Microsyst., Ecole Polytech. Fed. de Lausanne, Lausanne, Switzerland
Abstract :
We report on an innovative quadrupolar magnetic actuation system designed for performing immunoassays on-chip. Integrated magnetic microtips enable the retention and manipulation of functionalized superparamagnetic particles in a microfluidic channel. Actuation of dynamic bead plugs results in improved perfusion with sample solution thus enhanced analyte capture. The magnetic field parameters and kinetic properties of the bead plugs are discussed in detail. Improved protein capture efficiency is demonstrated with a model assay by means of fluorescent detection.
Keywords :
electric connectors; electromagnetic actuators; magnetic particles; microfluidics; photodetectors; proteins; superparamagnetism; dynamic bead plugs; fluorescent detection; immunoassays on-chip; integrated magnetic microtips; kinetic property; magnetic field parameters; microfluidic channel; perfusion; protein capture efficiency; quadrupolar magnetic actuation system; superparamagnetic particles; Fluorescence; Kinetic theory; Magnetic analysis; Magnetic fields; Magnetic properties; Microfluidics; Micromagnetics; Plugs; Proteins; System-on-a-chip; Superparamagnetic particles; immunoassay; magnetic actuation; microfluidics; protein capture;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285879
