Title :
Magnetic particle dosing, release and separation in a microfluidic chip with magnetic actuation
Author :
Afshar, R. ; Lehnert, T. ; Moser, Y. ; Gijs, M.A.M.
Author_Institution :
Lab. of Microsyst., Ecole Polytech. Fed. de Lausanne, Lausanne, Switzerland
Abstract :
Separation of functionalized magnetic particles or magnetically-labeled entities is an important tool in the field of bioanalysis. We present a novel integrated microfluidic magnetic bead separation device. On-chip manipulation of superparamagnetic beads is performed in a microfluidic channel under the influence of a highly focused magnetic field. Integrated magnetic microtips are used for retaining a defined amount of magnetic particles in a localized plug. This plug is released in a well-controlled way for subsequent particle separation with respect to their size and magnetic volume.
Keywords :
electromagnetic actuators; magnetic particles; microfluidics; bioanalysis; functionalized magnetic particles; magnetic actuation; magnetic bead separation device; magnetic particle dosing; magnetically-labeled entities; microfluidic channel; microfluidic chip; superparamagnetic beads; Coils; Magnetic fields; Magnetic particles; Magnetic separation; Microchannel; Microfluidics; Micromagnetics; Plugs; Proteins; Soft magnetic materials; Magnetic separation; magnetophoresis; microfluidics;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285882
