Two-dimensional label-free acetylcholine image sensor for imaging neuronal communication

Author

Takenaga, Shoko ; Lee, Seung-Ro ; Rahman, M.M. ; Takao, Hidekuni ; Ishida, Makoto ; Sawada, Kazuaki

Author_Institution

Dept. of Electr. & Electron. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan

fYear

2009

fDate

21-25 June 2009

Firstpage

975

Lastpage

978

Abstract

32times32 acetylcholine image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of acetylcholine distribution was carried out without label and a huge measurement. Acetylcholine imaging technology has a lot of potential for the early stage of Alzheimer´s disease, the release mechanism between terminal neurons. In addition, the proposed sensor is a very unique device due to not only determine quantity but also acquire real time imaging of behavior of biological matter. Therefore, the sensor has an infinite of possibility as a new tool in medical and biological field.

Keywords

CCD image sensors; CMOS image sensors; biochemistry; biomedical equipment; biomedical imaging; chemical sensors; neurophysiology; organic compounds; pH measurement; Alzheimer´s disease; CCD image sensor; CMOS image sensor; biological matter; neuronal communication; pH sensor; real time imaging; two-dimensional label-free acetylcholine image sensor; Alzheimer´s disease; Biochemistry; Biomedical imaging; Biosensors; CMOS technology; Charge coupled devices; Charge transfer; Charge-coupled image sensors; Fluorescence; Image sensors; ACh; CCD; enzyme reaction; image sensor;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International

Conference_Location

Denver, CO

Print_ISBN

978-1-4244-4190-7

Electronic_ISBN

978-1-4244-4193-8

Type

conf

DOI

10.1109/SENSOR.2009.5285980

Filename

5285980