Title :
Microtubule sortiing within a given electric field by designing flexural rigidity
Author :
Isozaki, Naoto ; Shintaku, Hirofumi ; Kotera, Hidetoshi ; Meyhofer, Edgar ; Yokokawa, Ryuji
Author_Institution :
Kyoto Univ., Kyoto, Japan
Abstract :
We propose a method to control gliding directions of kinesin-propelled microtubules (MTs) corresponding to their flexural rigidity (EI). We prepared two kinds of MTs having different EI and their trajectories within an electric field were clearly separated. Therefore, this study demonstrated the EI-altered MTs can be workhorses to sort/concentrate various combinations of target molecules loaded on MTs.
Keywords :
bioMEMS; biocontrol; electric fields; proteins; shear modulus; electric field; flexural rigidity; gliding direction control; kinesin-propelled microtubules; microtubule sorting; Electric fields; Equations; Mathematical model; Proteins; Reservoirs; Substrates; Trajectory;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2015 28th IEEE International Conference on
Conference_Location :
Estoril
DOI :
10.1109/MEMSYS.2015.7050932
