DocumentCode :
1880147
Title :
Fuzzy and quantum methods of information retrieval to analyse genomic data from patients at different stages of fibrosis
Author :
Sierocinski, Thomas ; Theret, Nathalie ; Petritis, Dimitri
Author_Institution :
Univ. de Rennes 1, Inst. de Rech. Math., Rennes
fYear :
2008
fDate :
25-28 Oct. 2008
Firstpage :
1
Lastpage :
5
Abstract :
We have recently introduced in a novel method of unsupervised clustering, we termed semantic distillation, inspired from the quantum theory of measurement, allowing to analyse statistical data and regroup objects according to their contextual specificity. Here we introduce an improvement of the method to make it applicable even in the more difficult case where data have very small statistical variability from sample to sample. We applied our method to a dataset from DNA arrays of different anatomopathological samples concerning 14 patients suffering from fibrosis. The clusters produced by our method have been automatically indexed by the evolutionary stage of the disease and the genes regrouped therein identified as responsible of biological processes specific for every stage.
Keywords :
DNA; bioinformatics; fuzzy logic; genomics; information retrieval; DNA array; fibrosis; fuzzy method; genomic data; information retrieval; quantum method; semantic distillation; unsupervised clustering; Bioinformatics; DNA; Data analysis; Fuzzy logic; Genomics; Information analysis; Information retrieval; Liver; Quantum mechanics; US Department of Transportation; DNA microarray; Quantum information retrieval; quantum and fuzzy logic; semantic distillation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Applied Sciences on Biomedical and Communication Technologies, 2008. ISABEL '08. First International Symposium on
Conference_Location :
Aalborg
Print_ISBN :
978-1-4244-2647-8
Electronic_ISBN :
978-1-4244-2648-5
Type :
conf
DOI :
10.1109/ISABEL.2008.4712599
Filename :
4712599
Link To Document :
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