Title :
A CMOS electrochemical impedance spectroscopy biosensor array for label-free biomolecular detection
Author :
Manickam, Arun ; Chevalier, Amelie ; McDermott, Maxwell ; Ellington, Andrew D ; Hassibi, Arjang
Author_Institution :
Univ. of Texas, Austin, TX, USA
Abstract :
A fully integrated 10×10 electrochemical impedance spectroscopy array is designed for label-free biomolecular detection applications. Each biosensor pixel includes an on-chip bio-functionalized electrode and a direct-conversion receiver capable of measuring complex admittance levels as low as 10·¿¿-1 with a dynamic range larger than 90 dB in a 10 Hz-to-50 MHz frequency range.
Keywords :
CMOS integrated circuits; DNA; biosensors; electrochemical impedance spectroscopy; electrodes; molecular biophysics; proteins; receivers; sensor arrays; CMOS electrochemical impedance spectroscopy biosensor array; biosensor pixel; complex admittance levels; direct-conversion receiver; frequency 10 Hz to 50 MHz; label-free biomolecular detection applications; on-chip bio-functionalized electrode; Biosensors; DNA; Detectors; Electrochemical impedance spectroscopy; Electrodes; Frequency measurement; Gold; Magnetic analysis; Proteins; Signal to noise ratio;
Conference_Titel :
Solid-State Circuits Conference Digest of Technical Papers (ISSCC), 2010 IEEE International
Conference_Location :
San Francisco, CA
Print_ISBN :
978-1-4244-6033-5
DOI :
10.1109/ISSCC.2010.5434019
