A non-enzymatic micro-needle patch sensor for freecholesterol continuous monitoring

Author

Yoon, H.S. ; Lee, S.J. ; Park, J.Y. ; Seung-Joon Paik ; Allen, Mark G.

Author_Institution

Dept. of Electron. Eng., Kwangwoon Univ., Seoul, South Korea

fYear

2014

fDate

2-5 Nov. 2014

Firstpage

347

Lastpage

350

Abstract

A patch type non-enzymatic free-cholesterol sensor was newly developed for continuous monitoring by using stainless steel based micro-needle patch and nanoporous platinum (NPt) sensing electrodes. The formed micro-needle patch was coated with parylene/gold/parylene film and selectively dry-etched to form the gold electrodes at the tips of micro-needles. The bare gold tips were finally electroplated with nanoporous platinum. The sensor was then characterized and analyzed by using cyclic voltammetry and chronoamperometry measurement techniques. The fabricated sensor exhibited high sensitivity of 305nA/mM·cm² and correlation coefficient of 0.964 in 0.1M PBS (pH 7.4). In the recovery test, recovery rate was more than 89%.

Keywords

amperometric sensors; biomedical equipment; electrochemical electrodes; electroplating; etching; gold; microsensors; nanomedicine; nanoporous materials; nanosensors; patient monitoring; platinum; thin film sensors; voltammetry (chemical analysis); NPt sensing electrodes; Pt-Au; chronoamperometry measurement; correlation coefficient; cyclic voltammetry; dry-etching; electroplating; free-cholesterol continuous monitoring; gold electrodes; nanoporous platinum; nanoporous platinum sensing electrodes; nonenzymatic microneedle patch sensor; parylene-gold-parylene film; recovery rate; stainless steel-based microneedle patch; Biosensors; Electric potential; Electrodes; Gold; Monitoring; Nanobioscience; Platinum; free-cholesterol; micro-needle patch; nanoporous platinum; non-enzyme;

fLanguage

English

Publisher

ieee

Conference_Titel

SENSORS, 2014 IEEE

Conference_Location

Valencia

Type

conf

DOI

10.1109/ICSENS.2014.6985005

Filename

6985005