Synthetic nanopores for molecular spectroscopy

A new technique to sequence single strand DNA by translocation through a synthetic graphene nanopore is discussed. An amplifier connecting the two sides of the nanopore produces a feedback signal sufficient for dielectrophoresis of ssDNA through the nanopore. The feedback signal also amplifies the size and electrical differences in the DNA bases as they translocate through the nanopore. Focused electron beam, focused ion beam and scanning tunneling current microscope probe were used to produce the graphene nanopore with only scanning tunneling probe reproducibly resulting in 1 nm pores.