Title :
Broad-band Mach-Zehnder Interferometry as a detection principle for label-free biochemical sensing
Author :
Kitsara, M. ; Raptis, I. ; Misiakos, K. ; Makarona, E.
Author_Institution :
Inst. of Microelectron, NCSR "Demokritos", Aghia Paraskevi
Abstract :
In this work the Broad-Band Mach-Zehnder Interferometry (BB-MZI) is presented as an alternative operation principle for optical biochemical sensors that will allow for ultra-sensitive, label-free, multi-analyte detection schemes. Simulation studies were performed for a Si-based MZI so as to explore its sensing capabilities in terms of the transmission output spectrum. The presented simulation results concern biochemical applications such as aqueous glucose solutions and hypothetical thin protein adlayers adsorbed on the sensing arm.
Keywords :
Mach-Zehnder interferometers; biochemistry; biosensors; chemical sensors; molecular biophysics; proteins; sugar; Si-based MZI; aqueous glucose solution; broadband Mach-Zehnder interferometry; hypothetical thin protein adlayers; label-free biochemical sensing; multianalyte detection scheme; optical biochemical sensors; transmission output spectrum; Biomedical optical imaging; Biosensors; Optical interferometry; Optical refraction; Optical ring resonators; Optical sensors; Optical surface waves; Optical variables control; Optical waveguides; Refractive index;
Conference_Titel :
Sensors, 2008 IEEE
Conference_Location :
Lecce
Print_ISBN :
978-1-4244-2580-8
Electronic_ISBN :
1930-0395
DOI :
10.1109/ICSENS.2008.4716594
