• DocumentCode
    1898234
  • Title

    Optimization criteria for DNA repair

  • Author

    Bustin, Ronit ; Messer, Hagit

  • Author_Institution
    Sch. of Electr. Eng., Tel Aviv Univ.
  • fYear
    2005
  • fDate
    17-20 July 2005
  • Firstpage
    1402
  • Lastpage
    1407
  • Abstract
    Engineers design error-correction systems to try to achieve zero error (that is, a perfect matching between the transmitted and the received code) while error-free transfer of genetic information from one generation to the other will stop evolution. That is, in biological systems, unlike the case of person-made systems, the target of error-correction procedures is to maintain a certain level of errors - not too high (to ensure the sustainability of the individual) and not too low - to ensure the sustainability of life. We suggest a two-part model for the communication of the genetic information from one generation to the other. The DNA repair process plays different role in each part of this model. In this paper we will focus only on the first part of the suggested model. We suggest RNA polymerase (RNAp) as the optimization criterion for the efficiency of this first part, that is, the "success" of the DNA repair process is a successful operation of the RNAp in spite of a lesion
  • Keywords
    DNA; biological techniques; error correction; genetic engineering; DNA repair; RNA polymerase; error-correction systems; genetic information; person-made systems; Biological system modeling; Biological systems; DNA; Design engineering; Evolution (biology); Genetic engineering; Lesions; Polymers; RNA; Systems engineering and theory;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Statistical Signal Processing, 2005 IEEE/SP 13th Workshop on
  • Conference_Location
    Novosibirsk
  • Print_ISBN
    0-7803-9403-8
  • Type

    conf

  • DOI
    10.1109/SSP.2005.1628815
  • Filename
    1628815