In Silico Simulation of Epidermal Growth Factor Signaling in Prostate Cancer Cells

The epidermal growth factor receptor (EGFR) and its signaling pathways are closely involved in the development and progression of prostate cancer. To understand the EGF-stimulated signaling pathways in prostate cancer cells, we constructed a mathematical model of EGF receptor signaling in PCRV cells based on the experimental data. The model was described by twenty-seven ordinary differential equations, and all parameters were estimated by genetic algorithm. The validity of the model was confirmed with time-course western blot data, showing that the model could successfully reproduce all experimental results.