Sensing of biomolecular motion of liposome and target protein, and their interaction by dielectric dispersion analysis for 100–1000 MHz range

We have newly examined biochemical interaction between liposome and target proteins by Dielectric Dispersion Analysis (DDA), especially for frequency range of 100-1000 MHz to consider molecular dynamics of the coexistence of the liposome membrane and target protein. Finally, we observed several new dielectric relaxations by the interaction in the low frequency range, thereafter we newly found and considered that some interaction manners between the each protein against liposome would exist and be different at least qualitatively for the two proteins because the manner of change in relaxation was different between each other. On the other hand, we have detected successfully much smaller dielectric relaxation even in narrower frequency range, thus also able to detect the change with much smaller concentration of protein than the previous works.