A Real-time Instrumentation System for the Study of Regional Deposition of Airborne Particles and Drug Delivery in the Human Respiratory System

Author

Gunarathne, G.P.P. ; Koujalagi, V. ; Semple, S. ; Ayres, J.G.

Author_Institution

Sch. of Eng., Robert Gordon Univ., Aberdeen

fYear

2008

fDate

12-15 May 2008

Firstpage

2015

Lastpage

2020

Abstract

This paper presents the work carried out in developing a precision, real-time bolus injection and breath-pattern analysis system to study the effect of regional deposition of fine particulate matter (PM) within the human respirator system. This new system computes parameters necessary and injects PM into breath cycles by a process of dynamic breadth pattern analysis and statistical data relating to PM stored under pressure taking into account such factors as agglomeration and aggregation of particles, to achieve a highly controlled delivery of bolus within specified exposure times and intervals.

Keywords

drug delivery systems; respiratory protection; airborne particles; breath-pattern analysis system; drug delivery; human respirator system; human respiratory system; particle agglomeration; particle aggregation; particulate matter; real-time bolus injection; real-time instrumentation system; regional deposition; Air pollution; Control systems; Drug delivery; Humans; Instruments; Lungs; Nanoparticles; Pattern analysis; Real time systems; Respiratory system; Agglomeration; Air pollution; Bolus injection; Nanoparticles; Respiratory disorders;

fLanguage

English

Publisher

ieee

Conference_Titel

Instrumentation and Measurement Technology Conference Proceedings, 2008. IMTC 2008. IEEE

Conference_Location

Victoria, BC

ISSN

1091-5281

Print_ISBN

978-1-4244-1540-3

Electronic_ISBN

1091-5281

Type

conf

DOI

10.1109/IMTC.2008.4547379

Filename

4547379