Title :
Modeling the Rearrangements of Genes Encoding Immune Receptors. Toward a Prediction Tool of Immune Specificity
Author :
Simonet, Maria-Ana ; Hansen, Olivier ; Thuderoz, Florence ; Jouvin-Marche, Evelyne ; Marche, Patrice N. ; Demongeot, Jacques
Author_Institution :
Labs. TMC-IMAG, Univ. J. Fourier, La Tronche
Abstract :
This paper describes a general random mechanism of vanishing the central part of a concatenated chain made of characters in an alphabet of cardinal 4. This mechanism allows to obtain chains shorter than the initial one with some constraint for the start and the end of the resulting chain. An application in immunology of this chain shortening procedure will be proposed, describing the genesis of new functional genes from the TCRAD locus on the chromosome 14 in mice and humans encoding immune receptors.
Keywords :
biology computing; genetics; TCRAD locus; chain shortening procedure; genes encoding immune receptors; immune specificity; prediction tool; Biological cells; Competitive intelligence; Concatenated codes; DNA; Encoding; Humans; Immune system; Laboratories; Mice; Probability distribution; T-Cell Receptor (TCR); V(D)J rearrangements; characters chains shortening; immunologic repertoire; mixture of probability distributions; random windowing;
Conference_Titel :
Complex, Intelligent and Software Intensive Systems, 2009. CISIS '09. International Conference on
Conference_Location :
Fukuoka
Print_ISBN :
978-1-4244-3569-2
Electronic_ISBN :
978-0-7695-3575-3
DOI :
10.1109/CISIS.2009.89
