Modeling the Rearrangements of Genes Encoding Immune Receptors. Toward a Prediction Tool of Immune Specificity

Author

Simonet, Maria-Ana ; Hansen, Olivier ; Thuderoz, Florence ; Jouvin-Marche, Evelyne ; Marche, Patrice N. ; Demongeot, Jacques

Author_Institution

Labs. TMC-IMAG, Univ. J. Fourier, La Tronche

fYear

2009

fDate

16-19 March 2009

Firstpage

943

Lastpage

948

Abstract

This paper describes a general random mechanism of vanishing the central part of a concatenated chain made of characters in an alphabet of cardinal 4. This mechanism allows to obtain chains shorter than the initial one with some constraint for the start and the end of the resulting chain. An application in immunology of this chain shortening procedure will be proposed, describing the genesis of new functional genes from the TCRAD locus on the chromosome 14 in mice and humans encoding immune receptors.

Keywords

biology computing; genetics; TCRAD locus; chain shortening procedure; genes encoding immune receptors; immune specificity; prediction tool; Biological cells; Competitive intelligence; Concatenated codes; DNA; Encoding; Humans; Immune system; Laboratories; Mice; Probability distribution; T-Cell Receptor (TCR); V(D)J rearrangements; characters chains shortening; immunologic repertoire; mixture of probability distributions; random windowing;

fLanguage

English

Publisher

ieee

Conference_Titel

Complex, Intelligent and Software Intensive Systems, 2009. CISIS '09. International Conference on

Conference_Location

Fukuoka

Print_ISBN

978-1-4244-3569-2

Electronic_ISBN

978-0-7695-3575-3

Type

conf

DOI

10.1109/CISIS.2009.89

Filename

5066904