Development of new cancer treatment using approved MRI contrast agent and induction heating device

Author

Nagae, Hideo ; Nagano, Isamu ; Yagitani, Satoshi ; Yamada, Sotoshi ; Katayama, Kanji ; Tazawa, Kenji ; Ikehata, Yoshio

Author_Institution

Kanazawa Univ., Kanazawa, Japan

fYear

2011

fDate

13-20 Aug. 2011

Firstpage

1

Lastpage

4

Abstract

MRI contrast agents, Feridex and Resovist have superparamagnetic substance as an active ingredients. Feridex does not show temperature rise under AC magnetic field. In contrast Resovist shows temperature rise under the same condition. We simulated the optimum frequency on Resovist using phantom and found it is 140 kHz. However treatable cancer volume was limited to 9cm³. We tried a fractionation of Resovist. One of the fractions was found to be effective by more than 6 times compared to the drug by itself. This result suggests that the hyperthermia in combination with the fraction and induction heating device is a promising treatment for cancer.

Keywords

biomedical MRI; cancer; hyperthermia; phantoms; radiation therapy; Feridex; MRI contrast agent; Resovist; cancer treatment; frequency 140 kHz; hyperthermia; induction heating device; phantom; Cancer; Drugs; Electromagnetic heating; Hyperthermia; Magnetic resonance imaging; Rabbits; Tumors;

fLanguage

English

Publisher

ieee

Conference_Titel

General Assembly and Scientific Symposium, 2011 XXXth URSI

Conference_Location

Istanbul

Print_ISBN

978-1-4244-5117-3

Type

conf

DOI

10.1109/URSIGASS.2011.6051352

Filename

6051352