Title :
Light-absorption spectroscopy of mutagen-DNA complex in presence of competing biologically active compounds
Author :
Iermak, Ie ; Woziwodzka, A. ; Gwizdek-Wisniewska, A. ; Piosik, J.
Author_Institution :
Inst. for Radiophys. & Electron., NAS of Ukraine, Kharkov, Ukraine
Abstract :
Mathematical analysis of absorption spectra of biologically active substances is presented. Two models of interactions of mutagen and caffeine with DNA analyzed and obtained binding parameters show good coincidence. Using different models, which take into account formation of various complexes, it is possible to calculate different binding parameters of such triple systems and choose the model describing corresponding system in the best way.
Keywords :
DNA; bio-optics; biochemistry; molecular biophysics; physiological models; absorption spectra; binding parameters; biologically active substances; caffeine; competing biologically active compounds; light absorption spectroscopy; mathematical analysis; mutagen-DNA complex; Absorption; Biological system modeling; DNA; Equations; Mathematical model; Optimization;
Conference_Titel :
General Assembly and Scientific Symposium, 2011 XXXth URSI
Conference_Location :
Istanbul
Print_ISBN :
978-1-4244-5117-3
DOI :
10.1109/URSIGASS.2011.6051380
