DocumentCode
1932022
Title
Light-absorption spectroscopy of mutagen-DNA complex in presence of competing biologically active compounds
Author
Iermak, Ie ; Woziwodzka, A. ; Gwizdek-Wisniewska, A. ; Piosik, J.
Author_Institution
Inst. for Radiophys. & Electron., NAS of Ukraine, Kharkov, Ukraine
fYear
2011
fDate
13-20 Aug. 2011
Firstpage
1
Lastpage
4
Abstract
Mathematical analysis of absorption spectra of biologically active substances is presented. Two models of interactions of mutagen and caffeine with DNA analyzed and obtained binding parameters show good coincidence. Using different models, which take into account formation of various complexes, it is possible to calculate different binding parameters of such triple systems and choose the model describing corresponding system in the best way.
Keywords
DNA; bio-optics; biochemistry; molecular biophysics; physiological models; absorption spectra; binding parameters; biologically active substances; caffeine; competing biologically active compounds; light absorption spectroscopy; mathematical analysis; mutagen-DNA complex; Absorption; Biological system modeling; DNA; Equations; Mathematical model; Optimization;
fLanguage
English
Publisher
ieee
Conference_Titel
General Assembly and Scientific Symposium, 2011 XXXth URSI
Conference_Location
Istanbul
Print_ISBN
978-1-4244-5117-3
Type
conf
DOI
10.1109/URSIGASS.2011.6051380
Filename
6051380
Link To Document