Title :
Dynamic multinuclear chemical shift imaging of tumors (H-1, F-19, P-31) during 5-Fluorouracil chemotherapy
Author :
Kim, H. ; Waluch, V. ; Singh, M. ; Presant, C.A. ; Wolf, W.
Author_Institution :
Univ. of Southern California, Los Angeles, CA, USA
Abstract :
On-line NMRS (nuclear magnetic resonance spectroscopy) 5-Fluorouracil (5FU), a potent antitumor agent, provides unique information that makes it possible to assess its chemotherapeutic effect in human tumors by measuring the temporal and spatial distribution of 5FU on an MRI/MRS (magnetic resonance imaging/magnetic resonance spectroscopy) system, such as the Siemens Magneton operating at Siemens 1.5/2 T. The authors have begun testing multiply tunable coils intended to allow proton image guided 1H, 19F, and 31 P spectroscopy. Aspects of the design of such coils and preliminary studies are presented. It is concluded that such coils, which allow the correlative assessment of tumor status and drug biodistribution, may provide a unique new dimension monitoring and guiding drug therapy in cancer patients, and in testing new drug therapies in experimental animals
Keywords :
biomedical NMR; chemical shift; patient treatment; 1.5 T; 2 T; 5-Fluorouracil chemotherapy; 19F; 1H; 31P; Siemens Magneton; antitumor agent; cancer patients; drug biodistribution; dynamic multinuclear chemical shift imaging; experimental animals; human tumors; medical imaging; multiply tunable coils; tumor status; Chemicals; Coils; Drugs; Humans; Magnetic resonance imaging; Medical treatment; Neoplasms; Nuclear magnetic resonance; Nuclear measurements; Spectroscopy;
Conference_Titel :
Nuclear Science Symposium and Medical Imaging Conference, 1992., Conference Record of the 1992 IEEE
Conference_Location :
Orlando, FL
Print_ISBN :
0-7803-0884-0
DOI :
10.1109/NSSMIC.1992.301523
