Direct measurement of directional disorder for ciliary metachronal wave

Author

Yi, W.J. ; Park, K.S. ; Lee, C.H. ; Rhee, C.S.

Author_Institution

Inst. of Med. & Biol. Eng., Seoul Nat. Univ., South Korea

Volume

3

fYear

2001

fDate

2001

Firstpage

2621

Abstract

The interrelationship of cilia and the directional disorder of the ciliary metachronal wave were analyzed using digital microscopic images. The degree of synchronization between ciliary beats was determined by the correlation. factor between two different spots. Principal axes of inertia were applied to find out the uniphase directions of beating cilia. The standard deviation of wave directions in a ROI was defined as a measure of ciliary wave disorder (CWD). The pooled mean of CWD was 22.9+/-8.73° in ROIs of 8 μm×8 μm and 25.4+/-6.46° in 32 μm×24 μm from the sphenoid sinus mucosa of 5 normal subjects. Our result shows that there is a considerable variation in metachronal wave directions of cilia beating on the epithelium.

Keywords

CCD image sensors; biomedical optical imaging; medical image processing; optical microscopy; pneumodynamics; 24 micron; 32 micron; 8 micron; CCD camera; ROI; beating cilia; cilia; ciliary beats; ciliary metachronal wave; ciliary wave disorder; correlation. factor; degree of synchronization; digital microscopic images; directional disorder direct measurement; epithelium; inverted microscope; metachronal wave directions; mucociliary systems; principal axes of inertia; respiratory tract; sphenoid sinus mucosa; standard deviation; uniphase directions; wave directions; Biomedical engineering; Biomedical imaging; Biomedical measurements; Educational institutions; Engineering in medicine and biology; Frequency synchronization; Image analysis; Measurement standards; Microscopy; Propulsion;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1017319

Filename

1017319