Title :
Ensemble Based Data Fusion from Parietal Region Event Related Potentials for Early Diagnosis of Alzheimer´s Disease
Author :
Balut, Brian A. ; Karnick, Matthew T. ; Green, Deborah ; Kounios, John ; Clark, Christopher M. ; Polikar, Robi
Author_Institution :
Rowan Univ., Glassboro
Abstract :
As a natural consequence of steady increase of average population age in developed countries, Alzheimer´s disease is becoming an increasingly important public health concern. The financial and emotional toll of the disease is exacerbated with lack of standard diagnostic procedures available at the community clinics and hospitals, where most patients are evaluated. In our recent preliminary results, we have reported that the event related potentials (ERPs) of the electroencephalogram can be used to train an ensemble-based classifier for automated diagnosis of Alzheimer´s disease. In this study, we present an updated alternative approach by combining complementary information provided by ERPs obtained from several parietal region electrodes. The results indicate that ERPs obtained from parietal region of the cortex carry substantial complementary diagnostic information. Specifically, the diagnostic ability of such an approach is substantially better, compared to the performance obtained by using data from any of the individual electrodes alone. Furthermore, the diagnostic performance of the proposed approach compares very favorably to that obtained at community clinics and hospitals.
Keywords :
bioelectric potentials; diseases; electroencephalography; learning (artificial intelligence); medical diagnostic computing; pattern classification; sensor fusion; Alzheimer disease; electroencephalogram; ensemble based data fusion; medical diagnosis; parietal region event related potential; pattern classification; Alzheimer´s disease; Biomarkers; Delay; Electrodes; Enterprise resource planning; Hospitals; Neural networks; Protocols; Senior citizens; USA Councils;
Conference_Titel :
Neural Networks, 2007. IJCNN 2007. International Joint Conference on
Conference_Location :
Orlando, FL
Print_ISBN :
978-1-4244-1379-9
Electronic_ISBN :
1098-7576
DOI :
10.1109/IJCNN.2007.4371335