Nerve fiber stimulation threshold for multiphase stimuli

Author

Beecroft, S.I. ; Alkhateeb, A. ; Gaumond, R.P.

Author_Institution

Bioeng. Program, Pennsylvania State Univ., University Park, PA, USA

fYear

1994

fDate

17-18 Mar 1994

Firstpage

67

Lastpage

68

Abstract

The authors determined the strength-duration curves for stimulus pulse waveforms of one, two, or three rectangular phases of alternating polarity. Stimuli represented the induced transmembrane current density for a voltage-clamped unmyelinated axon. For any pulse length, the one-phase pulse always required the least current density to cause an action potential, while the two-phase pulse always required the most. For short pulse lengths (<τ_m, time constant for sodium gate activation at resting potential), the three-phase pulse curve approached that of the one-phase pulse; for long pulse lengths (>τ_mem, time constant of the resting membrane), the three-phase pulse curve approached that of the two-phase pulse

Keywords

bioelectric phenomena; neurophysiology; physiological models; Na; action potential; alternating polarity; induced transmembrane current density; multiphase stimuli; nerve fiber stimulation threshold; rectangular phase; resting membrane time constant; resting potential; sodium gate activation; stimulus pulse waveforms; strength-duration curves; voltage-clamped unmyelinated axon; Biomedical engineering; Biomembranes; Coils; Current density; Equations; Magnetic flux; Nerve fibers; Pulse circuits; RLC circuits; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 1994., Proceedings of the 1994 20th Annual Northeast

Conference_Location

Springfield, MA

Print_ISBN

0-7803-1930-3

Type

conf

DOI

10.1109/NEBC.1994.305174

Filename

305174