A Model of the Subthalamo-Pallidal Network Undergoing Extrinsic Stimulation

Author

Leondopulos, Stathis S. ; Micheli-Tzanakou, Evangelia

Author_Institution

State Univ. of New Jersey, Piscataway

fYear

2007

fDate

12-17 Aug. 2007

Firstpage

2988

Lastpage

2992

Abstract

A model of the subthalamo-pallidal loop using integrate-and-fire neurons in conjunction with first order models of synaptic afferents, calcium and potassium currents, and a leaky sodium current exhibits activity similar to that recorded in the Subthalamic nucleus of Parkinson patients undergoing stereotactic neurosurgery and deep brain stimulation (DBS). In particular, by incorporating a negative feedback loop, the model produces inhibitory responses to individual DBS pulses and exhibits oscillations in the alpha and beta range (8-29 Hz). Moreover, an increase in either DBS stimulus energy or GPe spontaneous activity causes the oscillatory behavior to subside.

Keywords

bioelectric phenomena; brain models; calcium; diseases; neurophysiology; oscillations; potassium; sodium; surgery; Ca; K; Na; Parkinson patients; deep brain stimulation; extrinsic stimulation; integrate-and-fire neurons; leaky sodium current; negative feedback loop; oscillations; stereotactic neurosurgery; subthalamo-pallidal network; synaptic afferents; Biological neural networks; Brain modeling; Brain stimulation; Calcium; Laboratories; Negative feedback loops; Neurons; Neurosurgery; Satellite broadcasting; USA Councils;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Networks, 2007. IJCNN 2007. International Joint Conference on

Conference_Location

Orlando, FL

ISSN

1098-7576

Print_ISBN

978-1-4244-1379-9

Electronic_ISBN

1098-7576

Type

conf

DOI

10.1109/IJCNN.2007.4371436

Filename

4371436