Title :
Intracranial dual-mode IVUS transducer for image-guided brain therapy preliminary experiments
Author :
Herickhoff, Carl D. ; Wolf, Patrick D. ; Smith, S.W. ; Grant, Gerald A. ; Britz, Gavin W. ; Wilson, Christy M.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Abstract :
In this study, we investigated the feasibility of using 3.5-Fr IVUS catheters for minimally-invasive, image-guided hyperthermia treatment of tumors in the brain. Feasibility is demonstrated in two ways: 1) by fitting a 3.5-Fr IVUS catheter with a 5 × 0.5 × 0.22 mm PZT-4 transducer for 9-MHz imaging, and 2) by testing an identical transducer for therapy potential with 3.3-MHz CW excitation. The imaging transducer´s performance was compared to a 9-Fr, 9-MHz ICE catheter as a gold standard, visualizing a 2.5-cm cyst phantom and a post-mortem ovine brain. The therapy transducer was able to maintain a power output of 700 mW, achieving a temperature rise of +19°C at a depth of 1.5 mm in excised brain tumor tissue.
Keywords :
biomedical transducers; biomedical ultrasonics; brain; catheters; hyperthermia; phantoms; tumours; ultrasonic therapy; ultrasonic transducers; IVUS catheters; PZT-4 transducer; brain tumor treatment; continous wave excitation; cyst phantom; depth 1.5 mm; frequency 3.3 MHz; frequency 9 MHz; image guided brain therapy; imaging transducer performance; intracranial dual mode IVUS transducer; minimally invasive image guided hyperthermia; power 700 mW; size 0.22 mm; size 0.5 mm; size 2.5 cm; size 5 mm; therapy transducer; ultrasonic therapy; Catheters; Hyperthermia; Imaging; Prototypes; Transducers; Tumors; Ultrasonic imaging; dual-mode catheter transducer; intravascular ultrasound; ultrasound hyperthermia;
Conference_Titel :
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-0382-9
DOI :
10.1109/ULTSYM.2010.5935594
