Title :
Leporine model refinement for investigation of an ophthalmic dynamic light scattering instrument
Author :
Dubin, Stephen ; Ansari, Rafat R. ; Victor, Mary ; Koch, Seth ; Steinberg, Sheldon ; Vanwinkel, Tom ; Della Vecchia, M.
Author_Institution :
Sch. of Biomed. Eng., Sci. & Health Syst., Drexel Univ., Philadelphia, PA, USA
Abstract :
Evaluation of lens opacity is indispensable in human clinical monitoring as well as research. The rapid evolution of ophthalmic instrumentation impels the development of models which are anatomically and physiologically realistic; and, at the same time, minimally intrusive to the nonhuman animal subjects. Use of an appropriate dosage regimen and other technical refinements for administration of naphthalene in the rabbit can reliably cause lens opacity and chorioretinal changes with much diminished danger or distress
Keywords :
biomedical equipment; eye; light scattering; opacity; patient monitoring; anatomically realistic models; appropriate dosage regimen; human clinical monitoring; medical instrumentation; minimally intrusive research; naphthalene administration; nonhuman animal subjects; ophthalmic instrumentation; physiologically realistic models; rabbit experimental model; technical refinements; Animals; Biomedical monitoring; Humans; Instruments; Lenses; Light scattering; Medical diagnostic imaging; NASA; Rabbits; Testing;
Conference_Titel :
Bioengineering Conference, 1998. Proceedings of the IEEE 24th Annual Northeast
Conference_Location :
Hershey, PA
Print_ISBN :
0-7803-4544-4
DOI :
10.1109/NEBC.1998.664872
