Title :
Subharmonic spectroscopy of ultrasound contrast agents
Author :
Faez, Telli ; Emmer, Marcia ; Docter, Margreet ; Versluis, Michel ; De Jong, Nico
Author_Institution :
Biomed. Eng. Thoraxcenter, Erasmus Med. Center, Rotterdam, Netherlands
Abstract :
We have investigated the subharmonic vibration of BR14 (Bracco Research S.A., Geneva, Switzerland) contrast agent microbubbles between 8-11 MHz. The response of the bubbles is recorded optically with the ultrafast recording camera (Brandaris 128) at three acoustic pressures 50, 100 and 120 kPa. The vibration of the microbubbles as a function of excitation frequency is measured and frequency content is determined. 40% of studied bubbles show subharmonic oscillations. For bubbles smaller than 3μm in diameter the driving frequency of maximum subharmonic response increases for increasing pressures opposite to what has been reported for larger bubbles (>; 3μm).
Keywords :
biomedical optical imaging; biomedical ultrasonics; bubbles; BR14 contrast agent microbubbles; excitation frequency; frequency 8 MHz to 11 MHz; pressure 100 kPa; pressure 120 kPa; pressure 50 kPa; subharmonic oscillations; subharmonic spectroscopy; subharmonic vibration; ultrafast recording camera; ultrasound contrast agents; Acoustics; Frequency measurement; Imaging; Oscillators; Presses; Resonant frequency; Ultrasonic imaging;
Conference_Titel :
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-0382-9
DOI :
10.1109/ULTSYM.2010.5935706