Numerical modelling as a design optimisation tool for DNA electrophoresis

A two-dimensional finite-element flux-corrected transport algorithm developed for the solution of gas discharge problems is employed in the field of microfabricated electrophoretic devices used for DNA sequencing. This will assist in a comprehensive study of sample loading and injection in sample injectors in DNA electrophoresis and optimise system design. Results for the initial stages of loading and injection without pullback are introduced. Preliminary design optimisation investigates the adjustment of the pullback voltage for minimum DNA "leakage". The results demonstrate the capabilities of the numerical algorithm as a design and optimisation tool for DNA electrophoresis.