Title :
3-D Finite Element Poisson-Nernst-Planck model for the analysis of ion transport across ionic channels
Author :
Coco, S. ; Gazzo, D.S.M. ; Laudani, A. ; Pollicino, G.
Author_Institution :
DIEES, Catania Univ.
Abstract :
A 3-D finite element steady-state Poisson-Nernst-Planck model is presented and applied to the analysis of the ion transport across ionic channels of cellular membrane. The model allows us to obtain an accurate description of ion flow across the cell membrane. An example of application to the case of a K channel is also illustrated. The resulting current-voltage curve for the K channel shows excellent agreement with experimental measurements
Keywords :
Poisson equation; biomembranes; cellular biophysics; channel flow; finite element analysis; 3D finite element Poisson-Nernst-Planck model; cellular membrane; current-voltage curve; ion flow; ion transport analysis; ionic channels; Atomic measurements; Biomembranes; Cells (biology); Electric potential; Finite element methods; Geometry; Newton method; Poisson equations; Solid modeling; Steady-state;
Conference_Titel :
Electromagnetic Field Computation, 2006 12th Biennial IEEE Conference on
Conference_Location :
Miami, FL
Print_ISBN :
1-4244-0320-0
DOI :
10.1109/CEFC-06.2006.1633067
