Principle and Analysis of a Two-dimensional On Chip Magnetophoresis of Bioparticles for Contamination-free Biochemical Reactors

Author

Chetouani, H. ; Jeandey, C. ; Haguet, V. ; Rostaing, H. ; Dieppedale, C. ; Reyne, G.

Author_Institution

Lab. d´´Electrotechnique de Grenoble, ENSIEG, St. Martin d´´Heres

fYear

0

fDate

0-0 0

Firstpage

445

Lastpage

445

Abstract

A new on chip magnetic device was designed, fabricated and tested. This system enables precise contactless arrangement, arraying and trapping of diamagnetic microbeads. The device is composed of holes matrix throughout thick CoPt magnetic layers electroplated on silicon wafer. The device was experienced with diamagnetic polystyrene-latex beads of mean diameter 3 urn in a paramagnetic buffered solution. Using this system, diamagnetic micron-sized beads were successfully controlled and trapped in spatial stable levitation within magnetic wells. Contactless passive levitation brings amazing possibilities to bio-chips. Compared with existing approaches, it allows precise passive contactless arraying of microbeads or unlabelled cells and enables contamination-free biochemical micro-reactors

Keywords

bioreactors; cobalt alloys; diamagnetic materials; electroplating; magnetic devices; magnetic levitation; magnetic particles; magnetic thin films; magnetic traps; paramagnetic materials; platinum alloys; biochips; bioparticles; contactless arraying; contactless passive levitation; contamination-free biochemical microreactors; diamagnetic microbeads; diamagnetic polystyrenelatex beads; magnetic wells; on chip magnetic device; paramagnetic buffered solution; silicon wafer; spatial stable levitation; thick magnetic layers; two-dimensional on chip magnetophoresis; Biochemical analysis; Digital video broadcasting; Fabrication; Gold; Inductors; Magnetic analysis; Magnetic levitation; Magnetic susceptibility; Paramagnetic materials; Resists;

fLanguage

English

Publisher

ieee

Conference_Titel

Electromagnetic Field Computation, 2006 12th Biennial IEEE Conference on

Conference_Location

Miami, FL

Print_ISBN

1-4244-0320-0

Type

conf

DOI

10.1109/CEFC-06.2006.1633235

Filename

1633235