Alzheimer disease detection and analysis using P3 component of ERP in Alzheimer type dementia

Author

Park, E.H. ; Cho, S.Y. ; Kim, J.W. ; Whang, W.W. ; Kim, H.T.

Author_Institution

Dept. of Psychol., Korea Univ., Seoul, South Korea

Volume

1

fYear

2001

fDate

2001

Firstpage

961

Abstract

This study is to develop the Alzheimer´s disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball task in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P3 components were compared among 4 groups. The relationship between P3 measures and neuro psychological test scores were evaluated by correlations. The latency of the target P3a and P3b was prolonged in AD and the effects were correlated with the severity of dementia. The P3 amplitude was not affected significantly in AD. There´s no difference between normal aged group and young group. These results suggest that the P3 component is specifically affected by Alzheimer type dementia.

Keywords

auditory evoked potentials; diseases; electroencephalography; medical signal detection; medical signal processing; Alzheimer disease detection; Alzheimer type dementia; age-matched normal aged controls; auditory oddball task; event-related potential P3; neuropsychological test scores; target P3 components; young controls; Aging; Alzheimer´s disease; Delay; Dementia; Electroencephalography; Enterprise resource planning; Medical control systems; Medical diagnostic imaging; Psychology; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE

ISSN

1094-687X

Print_ISBN

0-7803-7211-5

Type

conf

DOI

10.1109/IEMBS.2001.1019109

Filename

1019109