Study on normal appearing white matter of multiple sclerosis by texture analysis and modeling with MRI

In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) has markedly improved our ability to detect the macroscopic abnormalities of the brain and spinal cord, but brain white matter microcosmic research was few. Texture analysis was performed in different normal appearing white matter MRI unit on T2-weighted images from one patient with multiple sclerosis. The goal of this study was a exploration on microcosmic variety of brain white matter for patient with multiple sclerosis. Each selected brain white matter region of interest was divided into three groups according to vertical up or down or horizontal direction from single signal focus. Each extracted texture parameters was variational following the distance between signal focus and ROI. And texture parameter model was described.