• DocumentCode
    1988687
  • Title

    Prediction of protein function using signal processing of biochemical properties

  • Author

    Gopalakrishnan, Krishna ; Najarian, Kayvan

  • Author_Institution
    Dept. of Comput. Sci., North Carolina Univ., Charlotte, NC, USA
  • fYear
    2003
  • fDate
    11-14 Aug. 2003
  • Firstpage
    536
  • Lastpage
    538
  • Abstract
    We present a technique to find the biological function of protein from its primary sequence. Currently used protein classification methods make use of multiple alignments. We use signal-processing features obtained from the primary sequence of the protein, to predict its biological function. The primary sequence of protein is converted to signals based on the encoding of biochemical properties like hydrophobicity, solubility, molecular weight of constituent amino acids. Signal processing features like complexity, mobility and fractal dimension are extracted from the obtained signals. Studies are conducted for lipase, protease and isomerase of length between 100 and 200 amino acids.
  • Keywords
    biochemistry; molecular biophysics; molecular weight; organic compounds; proteins; signal processing; solubility; amino acids; biochemical property; biological function; complexity; encoding; fractal dimension; hydrophobicity; isomerase; lipase; mobility; molecular weight; multiple alignments; primary sequence; protease; proteins; signal-processing feature; solubility; Amino acids; Biochemical analysis; Biological information theory; Biomedical signal processing; Computer science; Encoding; Fractals; Proteins; Sequences; Signal processing;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE
  • Print_ISBN
    0-7695-2000-6
  • Type

    conf

  • DOI
    10.1109/CSB.2003.1227400
  • Filename
    1227400