DocumentCode
1988687
Title
Prediction of protein function using signal processing of biochemical properties
Author
Gopalakrishnan, Krishna ; Najarian, Kayvan
Author_Institution
Dept. of Comput. Sci., North Carolina Univ., Charlotte, NC, USA
fYear
2003
fDate
11-14 Aug. 2003
Firstpage
536
Lastpage
538
Abstract
We present a technique to find the biological function of protein from its primary sequence. Currently used protein classification methods make use of multiple alignments. We use signal-processing features obtained from the primary sequence of the protein, to predict its biological function. The primary sequence of protein is converted to signals based on the encoding of biochemical properties like hydrophobicity, solubility, molecular weight of constituent amino acids. Signal processing features like complexity, mobility and fractal dimension are extracted from the obtained signals. Studies are conducted for lipase, protease and isomerase of length between 100 and 200 amino acids.
Keywords
biochemistry; molecular biophysics; molecular weight; organic compounds; proteins; signal processing; solubility; amino acids; biochemical property; biological function; complexity; encoding; fractal dimension; hydrophobicity; isomerase; lipase; mobility; molecular weight; multiple alignments; primary sequence; protease; proteins; signal-processing feature; solubility; Amino acids; Biochemical analysis; Biological information theory; Biomedical signal processing; Computer science; Encoding; Fractals; Proteins; Sequences; Signal processing;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE
Print_ISBN
0-7695-2000-6
Type
conf
DOI
10.1109/CSB.2003.1227400
Filename
1227400
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