Title :
A Comprehensive Fuzzy-Based Framework for Cancer Microarray Data Gene Expression Analysis
Author :
Wang, Zhenyu ; Palade, Vasile
Author_Institution :
Oxford Univ., Oxford
Abstract :
In this paper, we employ fuzzy techniques for analysing cancer microarray gene expression data. A fuzzy-based ensemble model and a comprehensive fuzzy-based framework for cancer microarray data analysis are being proposed. Our methods were tested on three benchmark microarray cancer data sets, namely Leukemia Cancer Data Set, Colon Cancer Data Set and Lymphoma Cancer Data Set. Comparing to other traditional statistical and machine learning models, the new approach can efficiently tackle several key problems in cancer microarray gene expression data analysis, including highly correlated genes, high dimensionality, highly noisy data and further explanation of the diagnosis results.
Keywords :
biological organs; cancer; fuzzy neural nets; fuzzy systems; genetics; medical computing; tumours; cancer microarray data analysis; colon cancer data set; fuzzy-based ensemble model; fuzzy-based framework; gene expression analysis; leukemia cancer data set; lymphoma cancer data set; Benchmark testing; Cancer; Colon; Data analysis; Fuzzy systems; Gene expression; Humans; Laboratories; Learning systems; Machine learning;
Conference_Titel :
Bioinformatics and Bioengineering, 2007. BIBE 2007. Proceedings of the 7th IEEE International Conference on
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-1509-0
DOI :
10.1109/BIBE.2007.4375680