• DocumentCode
    1994244
  • Title

    A modified algorithm for DNA motif finding and ranking considering variable length motif and mutation

  • Author

    Ashrafi, Adnan Ferdous ; Iqtidar Newaz, A.K.M. ; Ajwad, Rasif ; Tanvee, Moin Mahmud ; Mottalib, M.A.

  • Author_Institution
    Dept. of CSE, Islamic Univ. of Technol., Gazipur, Bangladesh
  • fYear
    2015
  • fDate
    9-11 July 2015
  • Firstpage
    12
  • Lastpage
    17
  • Abstract
    With the evolution of time the gene composition of species have changed a lot. Consequently it has mutated to generate new diseases and traits. In order to identify genes or coding sections of a DNA sequence it is imperative to find out the promoter regions or the conserved regions of the DNA code first. But the main problem stands that the databases for these information are quite messy and needs to be researched. The main problems in finding motifs in a DNA sequence are finding a good and fast algorithm, considering mutations in those motifs, representing variable length motifs and being species generic. In this paper we tried to formulate a new algorithm which is fast, accurate and effective. Instead of general string matching of DNA sequences we have done integer mapping and matching which are comparatively fast and accurate. Besides in order to formulate a complete DNA motif finding algorithm we also need a generalized and rational fitness function for evaluating the potential motifs. Thus we have formulated a desirable fitness function that enables us to compare the relativity among potential motifs and finally to predict a certain motif for the input DNA sequences.
  • Keywords
    biocomputing; file organisation; DNA motif finding; DNA motif ranking; DNA sequence string matching; fitness function; hash table; integer mapping; integer matching; variable length motif; Algorithm design and analysis; Bioinformatics; Complexity theory; DNA; Genomics; Indexes; Mathematical model; De Novo Motif Finding; Fitness Function; Hash Table; Integer matching; Motifs; Mutation;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Recent Trends in Information Systems (ReTIS), 2015 IEEE 2nd International Conference on
  • Conference_Location
    Kolkata
  • Type

    conf

  • DOI
    10.1109/ReTIS.2015.7232844
  • Filename
    7232844