Development and testing of a simulated closed loop drug delivery system for congestive heart failure patients under milrinone administration

Author

Shah, Runa ; Bekker, Alex Y. ; Reisman, Stanley

Author_Institution

New Jersey Inst. of Technol., Newark, NJ, USA

fYear

2000

fDate

2000

Firstpage

49

Lastpage

50

Abstract

A simulated closed loop drug delivery system is developed and tested for its ability to maintain cardiac output at setpoint range for congestive heart patient model by adjusting the infusion of the inotropic PDE III inhibitor milrinone. The performance of the cascade controlling mechanism is robust in maintaining the physiological response at the desire setpoint range by the infusion of the drug. Results lead to the possibility of developing a clinical closed loop control system for congestive heart failure patients under milrinone administration

Keywords

biocontrol; cardiovascular system; cascade control; closed loop systems; drug delivery systems; feedback; flow control; physiological models; three-term control; transient response; PID controller; cardiac output; cardiovascular system model; cascade controlling mechanism; closed loop drug delivery system; congestive heart failure patient model; feedback control model; inotropic PDE III inhibitor infusion; milrinone administration; physiological response; robust performance; setpoint range; simulated system; transient response; Adaptive control; Brain modeling; Delay; Drug delivery; Heart; Medical simulation; Pharmaceutical technology; System testing; Three-term control; Transient response;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2000. Proceedings of the IEEE 26th Annual Northeast

Conference_Location

Storrs, CT

Print_ISBN

0-7803-6341-8

Type

conf

DOI

10.1109/NEBC.2000.842373

Filename

842373