Title :
Development and testing of a simulated closed loop drug delivery system for congestive heart failure patients under milrinone administration
Author :
Shah, Runa ; Bekker, Alex Y. ; Reisman, Stanley
Author_Institution :
New Jersey Inst. of Technol., Newark, NJ, USA
Abstract :
A simulated closed loop drug delivery system is developed and tested for its ability to maintain cardiac output at setpoint range for congestive heart patient model by adjusting the infusion of the inotropic PDE III inhibitor milrinone. The performance of the cascade controlling mechanism is robust in maintaining the physiological response at the desire setpoint range by the infusion of the drug. Results lead to the possibility of developing a clinical closed loop control system for congestive heart failure patients under milrinone administration
Keywords :
biocontrol; cardiovascular system; cascade control; closed loop systems; drug delivery systems; feedback; flow control; physiological models; three-term control; transient response; PID controller; cardiac output; cardiovascular system model; cascade controlling mechanism; closed loop drug delivery system; congestive heart failure patient model; feedback control model; inotropic PDE III inhibitor infusion; milrinone administration; physiological response; robust performance; setpoint range; simulated system; transient response; Adaptive control; Brain modeling; Delay; Drug delivery; Heart; Medical simulation; Pharmaceutical technology; System testing; Three-term control; Transient response;
Conference_Titel :
Bioengineering Conference, 2000. Proceedings of the IEEE 26th Annual Northeast
Conference_Location :
Storrs, CT
Print_ISBN :
0-7803-6341-8
DOI :
10.1109/NEBC.2000.842373
