Title :
Intelligent interpretation of PCR products in 1D gels for automatic molecular diagnostics
Author :
Pathak, Dhiraj K. ; Perlin, Mark W.
Author_Institution :
Sch. of Comput. Sci., Carnegie Mellon Univ., Pittsburgh, PA, USA
Abstract :
An important step in molecular diagnostics for genetic diseases is the interpretation of sizing signals obtained by gel electrophoresis. Usually, the interpretation is done manually and is labor-intensive. An algorithm for automatic interpretation of two-dimensional sizing signals is described. The underlying computation is a rule-based assignment of values to labels of a set of image variables
Keywords :
DNA; cellular biophysics; electrophoresis; gels; knowledge based systems; medical diagnostic computing; medical signal processing; molecular biophysics; patient diagnosis; 1D gels; 2D sizing signals; PCR products; algorithm; automatic interpretation; automatic molecular diagnostics; gel electrophoresis; genetic diseases; image variables; intelligent interpretation; rule-based assignment of values; Bioinformatics; Computer science; DNA; Diseases; Electrokinetics; Fluorescence; Genetics; Genomics; Humans; Testing;
Conference_Titel :
Computer-Based Medical Systems, 1994., Proceedings 1994 IEEE Seventh Symposium on
Conference_Location :
Winston-Salem, NC
Print_ISBN :
0-8186-6256-5
DOI :
10.1109/CBMS.1994.315994
