Neuroplastic alterations accompanying long-term depression in the anesthetized rat hippocampus

Author

Blaise, J. Harry ; Bronzino, J.D.

Author_Institution

Dept. of Electr. & Syst. Eng., Connecticut Univ., Storrs, CT, USA

fYear

2000

fDate

2000

Firstpage

99

Lastpage

100

Abstract

The major goals of this study were to: (1) assess whether low-frequency stimulation (LFS) is effective at inducing long-term depression (LTD) of the perforant path/dentate gyrus synapse in the anesthetized adult rat hippocampus, and (2) determine the frequency at which the shift from LTD to LTP occurs. Measures of homosynaptic LTD were recorded in the dentate gyrus during experiments conducted on anesthetized adult rats, Our results indicate that stimulation frequencies lower than or equal to 7 Hz resulted in the induction of LTD of both PSA and EPSP slope measures, with a shift to LTP occurring approximately between 11 and 30 Hz stimulation

Keywords

brain; neurophysiology; anesthetized rat hippocampus; evoked field potentials; long-term depression; low-frequency stimulation; neuroplastic alterations; perforant path/dentate gyrus synapse; synapse modification; synaptic plasticity; Biomedical engineering; Biomedical measurements; Educational institutions; Electrodes; Frequency measurement; Hippocampus; Neuroplasticity; Pulse measurements; Rats; Signal analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2000. Proceedings of the IEEE 26th Annual Northeast

Conference_Location

Storrs, CT

Print_ISBN

0-7803-6341-8

Type

conf

DOI

10.1109/NEBC.2000.842398

Filename

842398