Title :
Live demonstration: A CMOS-based lab-on-chip array for combined magnetic manipulation and opto-chemical sensing
Author :
Goh, Zheng Da Clinton ; Georgiou, Pantelis ; Constandinou, Timothy G. ; Prodromakis, Themistoklis ; Toumazou, Christofer
Author_Institution :
Dept. of Bioeng., Imperial Coll. London, London, UK
Abstract :
This paper presents a CMOS-based lab-on-chip platform for combined magnetic manipulation and opto-chemical sensing. Within each pixel, a Programmable Gate (PG) ISFET chemical sensor is combined with an active pixel sensor, and is encompassed within an inductive coil. The integrated pixel is tesselated to form an 8 × 8 array. Fabricated in a commercially available 0.35 μm CMOS technology, the system can be used for simultaneous optical imaging and pH sensing, and includes auto- calibration mechanisms for eliminating sensor non-idealities. A spatiotemporal magnetic field pattern generator has also been embedded for micro-scale magnetic manipulation. Controlled via a MATLAB based graphical user interface, the system achieves real time data acquisition at 6 fps, a pH sensitivity of 57 mV/pH and demonstrates magnetic manipulation of micro-beads.
Keywords :
CMOS image sensors; biosensors; calibration; chemical sensors; ion sensitive field effect transistors; lab-on-a-chip; microsensors; spatiotemporal phenomena; CMOS; ISFET; active pixel sensor; autocalibration mechanisms; data acquisition; graphical user interface; inductive coil; lab-on-chip array; microscale magnetic manipulation; optical imaging; optochemical sensor; pH sensor; programmable gate; size 0.35 mum; spatiotemporal magnetic field pattern generator; Arrays; Chemicals; Magnetic resonance imaging; Optical sensors; Pixel; Real time systems;
Conference_Titel :
Circuits and Systems (ISCAS), 2011 IEEE International Symposium on
Conference_Location :
Rio de Janeiro
Print_ISBN :
978-1-4244-9473-6
Electronic_ISBN :
0271-4302
DOI :
10.1109/ISCAS.2011.5937986
