Quantitative shear wave imaging of cell culture gels

Author

Orescanin, Marko ; Toohey, Kathleen S. ; Insana, Michael F.

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA

fYear

2009

fDate

20-23 Sept. 2009

Firstpage

483

Lastpage

486

Abstract

An ultrasonic shear wave imaging technique is being developed for estimating viscoelastic properties of hydrogels. A needle placed in the medium is vibrated along its axis to generate harmonic shear waves. Doppler pulses synchronously track shear wave propagation to estimate the local speed. Fitting shear-wave speed estimates to the dispersion relation obtained from two rheological models, we estimate the complex shear modulus, viz., elastic and viscous components. The dispersion equation estimated using the standard solid-body (Zener) model is compared to that from the Kelvin-Voigt model to explore the frequency landscape of hydrogel viscoelasticity within the 50-450 Hz shear wave bandwidth. We found both models give comparable estimates that each agree with independent rheometer measurements obtained at lower strain rates, as might be expected form these highly elastic gels.

Keywords

biomedical materials; biomedical ultrasonics; dispersion relations; hydrogels; ultrasonic imaging; viscoelasticity; Kelvin-Voigt model; Zener model; cell culture gels; dispersion relation; harmonic shear wave; hydrogel; rheological model; shear modulus; ultrasonic shear wave imaging; viscoelastic property estimation; Dispersion; Elasticity; Equations; Frequency estimation; Needles; Rheology; Solid modeling; Strain measurement; Ultrasonic imaging; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2009 IEEE International

Conference_Location

Rome

ISSN

1948-5719

Print_ISBN

978-1-4244-4389-5

Electronic_ISBN

1948-5719

Type

conf

DOI

10.1109/ULTSYM.2009.5441635

Filename

5441635