Title :
Quantitative shear wave imaging of cell culture gels
Author :
Orescanin, Marko ; Toohey, Kathleen S. ; Insana, Michael F.
Author_Institution :
Dept. of Electr. & Comput. Eng., Univ. of Illinois at Urbana-Champaign, Urbana, IL, USA
Abstract :
An ultrasonic shear wave imaging technique is being developed for estimating viscoelastic properties of hydrogels. A needle placed in the medium is vibrated along its axis to generate harmonic shear waves. Doppler pulses synchronously track shear wave propagation to estimate the local speed. Fitting shear-wave speed estimates to the dispersion relation obtained from two rheological models, we estimate the complex shear modulus, viz., elastic and viscous components. The dispersion equation estimated using the standard solid-body (Zener) model is compared to that from the Kelvin-Voigt model to explore the frequency landscape of hydrogel viscoelasticity within the 50-450 Hz shear wave bandwidth. We found both models give comparable estimates that each agree with independent rheometer measurements obtained at lower strain rates, as might be expected form these highly elastic gels.
Keywords :
biomedical materials; biomedical ultrasonics; dispersion relations; hydrogels; ultrasonic imaging; viscoelasticity; Kelvin-Voigt model; Zener model; cell culture gels; dispersion relation; harmonic shear wave; hydrogel; rheological model; shear modulus; ultrasonic shear wave imaging; viscoelastic property estimation; Dispersion; Elasticity; Equations; Frequency estimation; Needles; Rheology; Solid modeling; Strain measurement; Ultrasonic imaging; Viscosity;
Conference_Titel :
Ultrasonics Symposium (IUS), 2009 IEEE International
Conference_Location :
Rome
Print_ISBN :
978-1-4244-4389-5
Electronic_ISBN :
1948-5719
DOI :
10.1109/ULTSYM.2009.5441635
