Title :
Acoustoelectronic method for the detection of electrical and mechanical properties of adhering cell cultures
Author :
Guhr, G. ; Brünig, R. ; Schmidt, H. ; Weihnacht, M.
Author_Institution :
Leibniz Inst. of Solid State & Mater. Res. Dresden, Dresden, Germany
Abstract :
In this paper a new tool to assess viscoelastic and dielectric properties of biological samples is presented. Shear horizontal polarized surface acoustic waves (SH-SAW) are used to detect the viscoelastic properties of biological samples. Therefore a one-port SAW resonator, with a fundamental mode of 85 MHz was developed. Its electrode structure can be used simultaneously to detect the dielectric behavior of the whole system by impedance spectroscopy (IS) while the frequency ranges from kHz to MHz. The applicability of the combination of both methods appearing as new tool is exemplarily shown by cell adhesion experiments performed with murine fibroblast cell line L929.
Keywords :
bioelectric phenomena; biological techniques; biomechanics; cellular biophysics; dielectric properties; elastic waves; surface acoustic wave resonators; surface acoustic waves; ultrasonic measurement; viscoelasticity; L929 murine fibroblast cell line; SAW resonator electrode structure; acoustoelectronic method; adhering cell cultures; cell adhesion experiments; cell electrical properties; cell mechanical properties; dielectric properties; electrical property detection; frequency 85 MHz; impedance spectroscopy; mechanical property detection; one port SAW resonator; polarised SH-SAW; shear horizontal surface acoustic waves; viscoelastic properties; Acoustic signal detection; Acoustic waves; Dielectrics; Elasticity; Electrodes; Mechanical factors; Polarization; Surface acoustic waves; Surface impedance; Viscosity; L929; cell adhesion process; cell based biosensor; impedance spectroscopy; surface acoustic wave;
Conference_Titel :
Ultrasonics Symposium (IUS), 2009 IEEE International
Conference_Location :
Rome
Print_ISBN :
978-1-4244-4389-5
Electronic_ISBN :
1948-5719
DOI :
10.1109/ULTSYM.2009.5441737
