DocumentCode :
2000177
Title :
Biological Response Modifier-a nanorobotics control system design for immunotherapy in cancer treatment
Author :
Karan, Sankar ; Majumder, Dwijesh Dutta ; Chaudhuri, Swapna
Author_Institution :
Inst. of Radiophys. & Electron., Calcutta Univ., Kolkata, India
fYear :
2012
fDate :
15-17 March 2012
Firstpage :
645
Lastpage :
650
Abstract :
Immune system is a complex network of highly specialized cells (such as lymphocytes) and organs, all of which work together to clear infection (antigens), such as bacteria, a virus or tumor cell, from the body. Biologic Response Modifiers (BRM), also called immunotherapy, is a type of treatment that mobilizes and trigger the body´s immune system. Our study concentrates on immunotherapeutic approach to determine the antitumor properties of a transmembrane glycopeptides of sheep red blood cells (SRBCs) known as S-LFA3 or T11TS. We also present the theory of self assembly for collaborative behavior of machines at the molecular scale (10-9 meter) in the perspective of the theory of cybernetics, the science of control, communication and computation with integration to complex man-machines systems for maintaining and protecting the human body against pathogens. Our study also concentrates on nano-robot control design by describing various molecular level systems along with system casualty, state notation and automata in the light of general systems theory. A detailed study for principal changes in immune reactivity and cellular architecture during the progressive development of intracranial neoplasms and an immunotherapeutic schedule with a novel BMR, the molecular nano robot, T11TS/S-LFA3 has been presented.
Keywords :
automata theory; cancer; control system synthesis; medical robotics; microrobots; patient treatment; automata; biological response modifier; cancer treatment; cellular architecture; collaborative behavior; cybernetics theory; immune reactivity; immune system; immunotherapeutic schedule; immunotherapy; intracranial neoplasm; man-machines system; nanorobotics control system design; sheep red blood cells; state notation; system casualty; transmembrane glycopeptides; Cancer; Cells (biology); Immune system; Nanobioscience; Self-assembly; Shape; Tumors; Biological Response Modifier (BMR); Brain tumors; Cybernetics; General Systems Theory; Immunotherapy; Nano-robotics; Targeted Drug Delivery;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Recent Advances in Information Technology (RAIT), 2012 1st International Conference on
Conference_Location :
Dhanbad
Print_ISBN :
978-1-4577-0694-3
Type :
conf
DOI :
10.1109/RAIT.2012.6194605
Filename :
6194605
Link To Document :
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