Title :
A modified QT-clustering algorithm over Gene Expression data
Author :
Choudhury, Nirupam ; Sarmah, Rosy ; Sarma, Suranjon
Author_Institution :
Dept. of CS & Eng., Tezpur Univ., Tezpur, India
Abstract :
Clustering is often one of the first steps in Gene Expression Analysis. In this paper we propose a modified-QT clustering algorithm for gene expression datasets that uses a modified Pearson´s correlation measure to identify the clusters in gene expression data. Experimental results show the efficiency of the proposed method over several real-life datasets. The proposed method has been found to be better than other comparable algorithms in terms of z-score and p-value measures of cluster quality.
Keywords :
biology computing; genetics; pattern clustering; statistical analysis; cluster quality; gene expression datasets; modified Pearson´s correlation measure; modified QT clustering algorithm; p-value measure; quality threshold clustering; z-score; Biological cells; Clustering algorithms; Correlation; DNA; Gene expression; Heuristic algorithms; Software algorithms; Clustering; Gene expression data; Microarray; Pearson´s correlation coefficient; p-value; z-score;
Conference_Titel :
Recent Advances in Information Technology (RAIT), 2012 1st International Conference on
Conference_Location :
Dhanbad
Print_ISBN :
978-1-4577-0694-3
DOI :
10.1109/RAIT.2012.6194618