Title :
The effect of microbubble to kin-like soft material
Author :
Obata, Kazuya ; Yoshida, Kenji ; Wantanabe, Y. ; Tsukamoto, Akira ; Ushida, Takashi
Author_Institution :
Dept. of Life & Med. Sci., Doshisha Univ, Kyotanabe, Japan
Abstract :
In order to understand the effect of microbubble driven by ultrasound to the skin, we tried to investigate the effect of bubble behaviors to the skin-life soft material, bovine gelatine MDCK cells cultured. Using high-speed video camera and fluorescene microscope, the bubble behaviors and the effect to the cells were investigated. Based on observations using high-speed video camera, it was found that the bubble behaviors applied pressure stimulus to the gelatine surface. The fluorescene observation demonstrated that cells were locally desquamated or dead.
Keywords :
biological effects of acoustic radiation; biological fluid dynamics; biomedical ultrasonics; bubbles; cellular effects of radiation; fluorescence; microfluidics; molecular biophysics; optical microscopy; skin; video cameras; applied pressure stimulus; bovine gelatine MDCK cells; bubble behaviors; cell culture; cell death; fluorescene microscope; gelatine surface; high-speed video camera; kin-like soft material; locally desquamated cells; microbubble; skin; ultrasound; Biological materials; Biomedical materials; Cameras; Cells (biology); Drugs; Epidermis; Frequency; Pharmaceutical technology; Skin; Ultrasonic imaging; cavitation; component; microbubble; skin; transdermal; ultrasound;
Conference_Titel :
Ultrasonics Symposium (IUS), 2009 IEEE International
Conference_Location :
Rome
Print_ISBN :
978-1-4244-4389-5
Electronic_ISBN :
1948-5719
DOI :
10.1109/ULTSYM.2009.5441929
