The effect of microbubble to kin-like soft material

Author

Obata, Kazuya ; Yoshida, Kenji ; Wantanabe, Y. ; Tsukamoto, Akira ; Ushida, Takashi

Author_Institution

Dept. of Life & Med. Sci., Doshisha Univ, Kyotanabe, Japan

fYear

2009

fDate

20-23 Sept. 2009

Firstpage

1799

Lastpage

1802

Abstract

In order to understand the effect of microbubble driven by ultrasound to the skin, we tried to investigate the effect of bubble behaviors to the skin-life soft material, bovine gelatine MDCK cells cultured. Using high-speed video camera and fluorescene microscope, the bubble behaviors and the effect to the cells were investigated. Based on observations using high-speed video camera, it was found that the bubble behaviors applied pressure stimulus to the gelatine surface. The fluorescene observation demonstrated that cells were locally desquamated or dead.

Keywords

biological effects of acoustic radiation; biological fluid dynamics; biomedical ultrasonics; bubbles; cellular effects of radiation; fluorescence; microfluidics; molecular biophysics; optical microscopy; skin; video cameras; applied pressure stimulus; bovine gelatine MDCK cells; bubble behaviors; cell culture; cell death; fluorescene microscope; gelatine surface; high-speed video camera; kin-like soft material; locally desquamated cells; microbubble; skin; ultrasound; Biological materials; Biomedical materials; Cameras; Cells (biology); Drugs; Epidermis; Frequency; Pharmaceutical technology; Skin; Ultrasonic imaging; cavitation; component; microbubble; skin; transdermal; ultrasound;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2009 IEEE International

Conference_Location

Rome

ISSN

1948-5719

Print_ISBN

978-1-4244-4389-5

Electronic_ISBN

1948-5719

Type

conf

DOI

10.1109/ULTSYM.2009.5441929

Filename

5441929